Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China
Identifieur interne : 005B07 ( Main/Exploration ); précédent : 005B06; suivant : 005B08Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China
Auteurs :Source :
- Science : (Washington, D.C.) [ 0036-8075 ] ; 2004.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Sixty-one SARS coronavirus genomic sequences derived from the early, middle, and late phases of the severe acute respiratory syndrome (SARS) epidemic were analyzed together with two viral sequences from palm civets. Genotypes characteristic of each phase were discovered, and the earliest genotypes were similar to the animal SARS-like coronaviruses. Major deletions were observed in the Orf8 region of the genome, both at the start and the end of the epidemic. The neutral mutation rate of the viral genome was constant but the amino acid substitution rate of the coding sequences slowed during the course of the epidemic. The spike protein showed the strongest initial responses to positive selection pressures, followed by subsequent purifying selection and eventual stabilization.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000855
- to stream PascalFrancis, to step Curation: 000135
- to stream PascalFrancis, to step Checkpoint: 000816
- to stream Main, to step Merge: 005F67
- to stream Main, to step Curation: 005B07
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China</title>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">04-0375012</idno>
<date when="2004">2004</date>
<idno type="stanalyst">PASCAL 04-0375012 INIST</idno>
<idno type="RBID">Pascal:04-0375012</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000855</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000135</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000816</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000816</idno>
<idno type="wicri:Area/Main/Merge">005F67</idno>
<idno type="wicri:Area/Main/Curation">005B07</idno>
<idno type="wicri:Area/Main/Exploration">005B07</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China</title>
</analytic>
<series><title level="j" type="main">Science : (Washington, D.C.)</title>
<title level="j" type="abbreviated">Science : (Wash. D.C.)</title>
<idno type="ISSN">0036-8075</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Science : (Washington, D.C.)</title>
<title level="j" type="abbreviated">Science : (Wash. D.C.)</title>
<idno type="ISSN">0036-8075</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus</term>
<term>Genotype</term>
<term>Molecular epidemiology</term>
<term>Molecular evolution</term>
<term>Severe acute respiratory syndrome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Evolution moléculaire</term>
<term>Epidémiologie moléculaire</term>
<term>Génotype</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Sixty-one SARS coronavirus genomic sequences derived from the early, middle, and late phases of the severe acute respiratory syndrome (SARS) epidemic were analyzed together with two viral sequences from palm civets. Genotypes characteristic of each phase were discovered, and the earliest genotypes were similar to the animal SARS-like coronaviruses. Major deletions were observed in the Orf8 region of the genome, both at the start and the end of the epidemic. The neutral mutation rate of the viral genome was constant but the amino acid substitution rate of the coding sequences slowed during the course of the epidemic. The spike protein showed the strongest initial responses to positive selection pressures, followed by subsequent purifying selection and eventual stabilization.</div>
</front>
</TEI>
<affiliations><list></list>
<tree></tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005B07 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 005B07 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= Main |étape= Exploration |type= RBID |clé= Pascal:04-0375012 |texte= Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China }}
This area was generated with Dilib version V0.6.33. |